Using multiple toolchains in the same project?

[YMba9g8j9CJp0wLoQf5y (iLikeCmake)]

This question has already been answered before:

How to make a visual studio solution with x64/x86 support?

I understand for most generators it doesn’t make sense to support multiple toolchains. However, I think Visual Studio should be the exception. Since most people except to be able to build 32/64 bit application with visual studio.